PTEN and ERG Molecular Networks in Prostate Cancer

Prognostic value of ERG, PTEN, CRISP3 and SPINK1 in predicting biochemical recurrence in prostate cancer

The established prognostic factors associated with prostatic adenocarcinoma are the Gleason score, pathological T staging and serum prostatic-specific antigen (PSA) level. However, these prognostic factors alone are not sufficient for predicting prognostic characteristics, including early stage or advanced prostate cancer, presence of metastasis or disease-related mortality. The purpose of the ...

PTEN and prostate cancer.

PTEN in Prostate Cancer

D.J. Tindall (ed.), Prostate Cancer: Biochemistry, Molecular Biology and Genetics, Protein Reviews 16, DOI 10.1007/978-1-4614-6828-8_4, © Mayo Clinic 2013 Abstract PTEN is one of the most commonly deleted/mutated tumor suppressor genes in human prostate cancer. As a lipid phosphatase and negative regulator of the PI3K/AKT/mTOR pathway, PTEN controls a number of cellular processes, including sur...

Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer.

BACKGROUND The associations of ERG overexpression with clinical behavior and molecular pathways of prostate cancer are incompletely known. We assessed the association of ERG expression with AR, PTEN, SPINK1, Ki-67, and EZH2 expression levels, deletion, and mutations of chromosomal region 3p14 and TP53, and clinicopathologic variables. METHODS The material consisted of 326 prostatectomies, 166...

molecular pathways in prostate cancer

results like other cancers, prostate cancer is caused by an accumulation of genetic alterations in a cell that drives it to malignant growth. specific genes and gene alterations have been suggested to play a role in its development and progression. aneuploidy, loss of heterozygosity, gene mutations, hypermethylation and inactivation of specific tumour suppressor genes such as gstpi, apc, mdr1, ...